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TP2315 |
Glatiramer Acetate
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Others
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Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS). |
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T4283 |
SRI-011381
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|
TGF-beta/Smad
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SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. |
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T13408 |
ZK824190
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Others
,
Serine Protease
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ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively). |
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T6403 |
Siponimod
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BAF-312 |
S1P Receptor
,
LPL Receptor
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|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... |
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T9125 |
Tolebrutinib
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PRN2246,SAR442168 |
BTK
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Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi... |
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T4031 |
S1p receptor agonist 1
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S1p-receptor-agonist-1 |
S1P Receptor
,
LPL Receptor
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S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. |
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T6923 |
Ozanimod
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RPC-1063 |
S1P Receptor
,
LPL Receptor
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|
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... |
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T6561 |
Laquinimod
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LAQ,ABR-215062 |
Apoptosis
,
Others
,
NF-κB
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Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy. |
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T5129 |
SRI-011381 hydrochloride
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SRI-011381 hydrochloride [1629138-41-5(free base)] |
TGF-beta/Smad
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SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. |
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T2558 |
Cladribine
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2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA |
Apoptosis
,
Adenosine deaminase
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|
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |
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T3044 |
(E/Z)-Teriflunomide
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Aubagio,HMR-1726,Flucyamide,A77 1726 |
Dehydrogenase
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(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis. |
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T31149 |
CYM5181
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CYM 5181,CYM-5181 |
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CYM5181 is related to the body's immune system and can be used to study multiple sclerosis, transplant rejection, and adult respiratory distress syndrome. |
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T61183 |
MRGPRX4 modulator-2
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|
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MRGPRX4 modulator-2 (compound 1-55) is a highly potent modulator of MRGPR X4, displaying antagonist activity against this receptor with an IC50 value of less than 100 nM. Its application in the research of autoimmune dis... |
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T62552 |
Ozanimod hydrochloride
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BMS-986374 hydrochloride,RPC-1063 hydrochloride |
S1P Receptor
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|
Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer a... |
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T67865 |
BJJF078
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|
Glutaminase
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BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, res... |
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T77416 |
Opicinumab
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BIIB033 |
Others
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|
Opicinumab (BIIB033) is a novel monoclonal antibody against LINGO-1 that may be used to prevent and delay acute optic neuritis and recurrent multiple sclerosis. |
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T7534 |
Teriflunomide
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A 77-1726 |
Others
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Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis. |
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T125901 |
14-Epiandrographolide
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|
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14-Epiandrographolide is a compound derived from the above-ground parts of Andrographis paniculata that induces cell differentiation and can be used in the study of multiple sclerosis. |
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T12177 |
Natalizumab
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Integrin
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Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. |
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T76713 |
Inebilizumab
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MEDI 551,MT-0551,16C4-aFuc,VIB-0551 |
Others
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|
Inebilizumab is a humanized anti-CD19 monoclonal antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used to treat a range of autoimmune diseases associated with CD19... |
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T73689 |
Daclizumab
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Ro 24-7375,Zenapax |
IL Receptor
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Daclizumab (Zenapax) is a humanized monoclonal antibody that specifically inhibits the alpha subunit of IL-2R-HA. Daclizumab (Zenapax) can inhibit the binding of IL-2 and IL-2R-HA through specific binding to CD25. Dacliz... |
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TQ0291 |
Firategrast
|
SB 683699 |
Integrin
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Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity... |
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T0511 |
Tolperisone hydrochloride
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Muscalm,Midocalm,Tolperisone HCl |
Sodium Channel
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Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyel... |
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T1065 |
Baclofen
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Lioresal |
GABA Receptor
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Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp... |
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T21618L |
Myelin Basic Protein (87-99) Acetate
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Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base) |
Others
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Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein (87-99) Ac... |
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T3701 |
MCC950
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CP-456773 |
NOD
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T11134 |
DZ2002
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Others
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DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibr... |
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T111959 |
IFB-088 acetate
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|
|
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IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... |
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T36454 |
1-Stearoyl-rac-glycerol
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|
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1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenes... |
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T3354 |
BIA 10-2474
|
BIA10-2474 |
FAAH
,
Autophagy
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BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o... |
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T28778 |
Silperisone HCl
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RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336 |
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Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperi... |
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T30960 |
CL 232468
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AEAD,CL-232468,CL232468 |
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CL 232468 may be used to treat multiple sclerosis. |
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T68427 |
MLN-3897 citrate
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|
|
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MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. |
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T29117 |
VSN-16
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VSN-16R,VSN 16R,VSN16R |
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VSN-16, a cannabinoid receptor agonist, is used potentially for the treatment of spasticity in multiple sclerosis. |
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T40116 |
IL-17A inhibitor 2
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IL-17A inhibitor 2 is an IL-17A inhibitor for treating psoriasis, rheumatoid arthritis, and multiple sclerosis. |
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T69899 |
WOBE437
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|
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WOBE437 is a selective endocannabinoid reuptake inhibitor which reduces disease progression in a mouse model of multiple sclerosis |
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T81580 |
Ozanezumab
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GSK1223249 |
|
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Ozanezumab (GSK1223249) is a monoclonal antibody targeting Nogo-A (neurite outgrowth inhibitor A). It is utilized in research related to amyotrophic lateral sclerosis (ALS) and multiple sclerosis [1]. |
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T26223 |
SR1555 HCl
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SR-1555,SR1555,SR 1555 |
|
|
SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been involved in the pathology of several autoimmune diseases such as rheumatoid arthriti... |
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T69320 |
Aminoquinuride
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|
|
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Aminoquinuride, also known as Surfen, is a proteoglycan binding agent that reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. Murine T cell activation is regulated by Surfen. |
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T30529 |
BMS-520
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|
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BMS-520 is a potent, selective S1P1 agonist that has shown impressive efficacy when administered orally in a rat model of arthritis and in a mouse model of experimental autoimmune encephalomyelitis (EAE) with multiple sc... |
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T77013 |
Frexalimab
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|
|
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Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1]. |
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T69153 |
T0510-3657
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|
|
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T0510-3657 is a selective activator of GPR17, inhibiting cAMP levels, with potential for playing a key role in the development of a treatment against diseases such as, multiple sclerosis, Parkinson disease, Alzheimer's d... |
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T81841 |
MBP (146-170)
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|
|
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Myelin Basic Protein (MBP) fragment 146-170 is utilized in the study of Multiple Sclerosis (MS) [1]. |
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T77160 |
Divozilimab
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|
|
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Divozilimab (BCD-132), a humanized monoclonal antibody targeting CD20 (CD20), is utilized in multiple sclerosis research [1]. |
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T72007 |
COR167
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COR167 is a CB2 agonist. It displayed potent immunomodulatory activity on immune cells from healthy subjects and patients with multiple sclerosis. It also showed protective effects on rat brain tissues toward ischemia an... |
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T81219 |
Sampeginterferon beta-1a
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BCD-054 |
|
|
Sampeginterferon beta-1a (BCD-054), a pegylated IFNβ-1a, is evaluated for its potential in research addressing remitting multiple sclerosis [1] [2]. |
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TP2080 |
ADWX 1
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|
|
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Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a mo... |
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T37815 |
PM226
|
PM 226 |
|
|
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microg... |
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T80875 |
Vatelizumab
|
GBR500 |
|
|
Vatelizumab (GBR500), a monoclonal antibody, specifically targets the α2 subunit (CD49b) of very late antigen-2 (VLA-2) and is utilized in multiple sclerosis research [1]. |
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T62870 |
FABPs ligand 6
|
|
|
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FABPs ligand 6 (MF6) is an inhibitor of FABP5 (Kd: 874 nM) and FABP7 (Kd: 20 nM), which can be used in the study of multiple sclerosis. |
